For moderate to severe Osteoarthritis:
2 capsules twice daily (at least 2-3 months), 15 minutes before meals.
For maintenance:
1 capsule twice daily, 15 minutes before meals.
For more information refer to http://www.ostesamin.com/ostesamin-plus-chondroitin.php
1 tablet (500 mg) twice daily
Note: The Arthritis Foundation of America recommends starting with a low dosage of 500 mg twice a day and increasing gradually to 1,000 mg twice a day. After starting MSM, allow a reasonable amount of time to notice any benefits.
For more information refer to http://www.ostesamin.com/oste-msm.php